MTS™ (MIC Test Strip)

Paper strips* for determining the Minimum Inhibitory Concentration (M.I.C.)


MIC Test Strip

Caratteristiche MIC Test Strip

The Liofilchem® MIC Test Strips is a quantitative assay for determining the Minimum Inhibitory Concentration (MIC) of antimicrobial agents against microorganisms to indicate appropriate patient treatment and for identifying resistance patterns. Liofilchem® MIC Test Strips are made of special high quality paper impregnated with a predefined concentration gradient of antibiotic, across 15 two-fold dilutions like those of a conventional MIC method.

On one side of the strip a MIC scale in µg/mL is displayed and a code that identifies the antimicrobial agent. The Liofilchem® MTS™ (MIC Test Strip) range comprises over 150 agents. Each agent is available as 10/pack (individually packed), 30/pack (individually packed) or 100/canister pack.

Descrizione MIC Test

Metodo MIC Test Strip


When the Liofilchem® MIC Test Strip is applied onto an inoculated agar surface, the preformed exponential gradient of antimicrobial agent is transferred into the agar matrix. After 18 hours incubation or longer, a symmetrical inhibition ellipse centered along the strip is formed. The MIC is read directly from the scale in terms of µg/mL, at the point where the edge of the inhibition ellipse intersects with the MIC Test Strip.

MTS™ technical sheets

FDA-cleared MTS™

View the complete range of MTS™ (MIC Test Strip)

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Antifungal Susceptibility Testing of Candida; Challenging the gold standard method.
I. Butler, C. Neri, J. Lambourne - Royal London Hospital

In vitro activity of isavuconazole against clinically relevant Trichosporon species: a comparative evaluation of EUCAST broth microdilution and MIC Test Strip methods.
E. C. Francisco, C. Dieleman, F. Hagen, A. L. Colombo 
Journal of Antimicrobial Chemotherapy, DOI:

Evaluation of Rezafungin Disk and Gradient Strip Antimicrobial Susceptibility Testing Devices against a Broad Panel of Wild-type and Fks Mutant Candida spp. Strains
A. Almaguer, J. Donatelli, F. Demetrio, S. Pomponio, J. B. Locke
ASM Microbe 2020

Gepotidacin LiofilchemMIC Test Strip Evaluation against Enterobacteriaceae, Staphylococcus aureus, Staphylococcussaprophyticusand Neisseria gonorrhoeae
C. Jakielaszek, J. Difranco-Fisher, L. Koeth, N. Scangarella-Oman
ASM Microbe 2018

Multi-Site Evaluation of Eravacycline MIC Test Strip (MTS) Compared To Broth Microdilution MICs
M. Olesky, A. Windau, D. Hardy, E. Palavecino, E. Carretto, L. Koeth
MAD-ID 2019

Multi-Site Evaluation of Meropenem/VaborbactamMIC Test Strip (MTS) Compared To Broth Microdilution MICs
L. Koeth, A. Windau, D. Hardy, J. Mortensen, O. Lomovskaya
ASM Microbe 2018

Comparison of Plazomicin MIC Test Strip and Broth Microdilution MIC Results for 125 Enterobacteriaceae
L. Koeth, J. DiFranco-Fisher, A.W. Serio
IDWeek 2018

Evaluation of MIC Strip Isavuconazole Test for Susceptibility Testing of Wild-Type and Non-Wild-Type Aspergillus fumigatus Isolates
M. C. Arendrup, P. Verweij,H. V. Nielsen

Comparison of Phenotypic Tests and an Immunochromatographic Assay and Development of a New Algorithm for Detection of OXA-48-like Carbapenemases
F. Koroska, S. Göttig, M. Kaase, J. Steinmann, S. Gatermann, J. Sommer, T. Wille, G. Plum, A. Hamprechtr
DOI: 10.1128/JCM.01929-16

Importance of "in vitro" synergism examinations on infections caused by multidrug-resistant pathogens
M. Knausz, A. Becker, R. Nikolova, E. Urbaán, A. Laázaár

Daptomycin-resistant Staphylococcus pettenkoferi of human origin
V. Savini, M. Kosecka, Ed Siegwart, R. Marrollo, E. Polilli, D. Palmieri, P. Fazii, E. Carretto, J. Miedzobrodzki, M. Bukowski

Evaluation of Ceftolozane-Tazobactam MIC Test Strip Compared to Broth Microdilution MIC for Enterobacteriaceae and Pseudomonas aeruginosa
L. M. Koeth, J. M. Difranco-Fisher
ASM Microbe 2016

Multi-Site Evaluation of Dalbavancin and Vancomycin MIC Test Strip Compared To Broth Microdilution MICs
L. M. Koeth, D. J. Hardy, T. R. Walsh
ASM Microbe 2016

Multicentric evaluation of the reliability and the reproducibility of synergy testing using the MIC test strip - synergy application system (MTS-SAS™)
E. Carretto, F. Brovarone, P. Gaibani, G. Russello, C. Farina

Evaluation of Dalbavancin MIC Test Strip (MTS) Compared to Broth Microdilution MIC for Relevant Gram Positive Isolates
L. M. Koeth, J. M. Difranco-Fisher, M. Dunne, S. Puttagunta, S. McCurdy
ICAAC 2015

Evaluation of in vitro synergy testing of South African invasive Salmonella Typhi isolates using the Liofilchem® MTS application system
Arvinda Sooka, Karen H. Keddy

Liofilchem® Chromatic VRE and vancomycin MIC Test Strip detected glycopeptide resistance in a vanB neonatal Enterococcus faecium isolate showing alternate vancomycin susceptibility and resistance with bioMérieux Vitek2
V. Savini, R. Marrollo, E. Coclite, P. Fusilli, C. D'Incecco, P. Fazii, G. Gherardi
Int J Clin Exp Pathol 2014;7(9):6274-6277

Impact of dosing frequency on azole's pharmacodynamics against Aspergillus fumigatus
A. Elefanti, M. Siopi, N. Siafakas, L. Zerva, J. Meletiadis
ICAAC 2014, Poster no. M-456

Comparison of four methods for the determination of tigecycline susceptibility in multi-resistant E. coli and K. pneumoniae
A. Hamprecht, E. Zander, T. Oestreicher, H. Seifert, P. G. Higgins
ECCMID 2014, Poster no. 352

Determination of the sensitivity and specificity of the MIC Test Strips (MTS) mechanisms of detection against in-house methods for 644 multi-drug resistant (MDR) strains: a European multi-centre study
Canton R.; Gniadkowski M.; Morosini M.; Pirs M.; Rossolini G.; Sukhorukova M.; Tsakris A.; Vrioni G.; Walsh T.R; Zabicka D.
ECCMID 2014, Poster no. 1009

Evaluation of a new phenotypic method to reveal AmpC presence and porin loss in enterobacteriaceae with decreased susceptibility to carbapenems
E. Carretto, D. Barbarini, F. Brovarone, G. Russello, M. Bardaro, F. Vailati, C. Farina
ECCMID 2014, Poster no. 354

Direct determination of antimicrobial susceptibility of Gram Negative Bacilli from respiratory samples on chromogenic agar plates with gradient antibiotic strips
C. d'Humières, M. Belhiba, F. Brocco, A. Andremont, N. Grall
ECCMID 2014, Poster no. 348

Efficacy of Fosmidomycin alone and in combination with colistin, tigecycline and rifampicin against multi-drug resistant and extensively drug resistant Enterobacteriaceae
J. Tyrrell, T. R. Walsh
ECCMID 2014, Poster no. 235

In vitro activity of colistin as single agent and in combination with antifungals against filamentous fungi occurring in patients with cystic fibrosis.
H. Schemuth, S. Dittmer, M. Lackner, L. Sedlacek, A. Hamprecht, E. Steinmann, J. Buer, P.-M. Rath and J. Steinmann
Mycoses, 2013, 56, 297–303

Détermination directe de la sensibilité aux antibiotiques des Bacilles à Gram Négatif dans les prélèvements respiratoires sur milieu chromogène avec bandelettes antibiotique
C. d'Humières, M. Belhiba, F. Brocco, A. Andremont, N. Grall
RICAI 2013, poster no. 314

Evaluation of Liofilchem® MIC Test Strips (MTS) gradient-diffusion system for susceptibility testing of multiresistant Pseudomonas aeruginosa and Acinetobacter strains.
M. Sukhorukova, E. Skleenova, A. Timokhova, A. Romanov, M. Edelstein (Smolensk, RU)

Evaluation of Liofilchem® MIC Test Strips (MTS) gradient-diffusion system for susceptibility testing of multiresistant Pseudomonas aeruginosa and Acinetobacter strains - Abstract in English
M. Sukhorukova, E. Skleenova, A. Timokhova, A. Romanov, M. Edelstein (Smolensk, RU)

Evaluation of a new method for detecting KPC-producing bacteria based on the combination of a screening medium and a gradient diffusion system
F. Brocco, D. Vitagliano, F. Demetrio
ECCMID 2013, e-Poster no. 690

A novel, direct susceptibility testing method of sonicated vascular prosthetic graft samples by combination of Liofilchem® MIC Test Strip and chromogenic agar plates
F.H. M’Zali, L. Stecken, X. Berard, A. Quinart, F. Sztark

Evaluation of gradient concentration strips for in vitro combination testing of antifungal combinations against Candida spp.
M. Siopi, A. Elefanti, N. Siafakas, L. Zerva, J. Meletiadis
ECCMID 2013, poster no. 976

Evaluation of MIC Test Strips (MTS) gradient-diffusion system for susceptibility testing of NDM-1 positive Klebsiella pneumoniae and Escherichia coli
J. Weeks, T. R. Walsh
ECCMID 2013, poster no. 1554

Synergistic effects of rifampicin, nitrofurantoin, fosfomycin and colistin against NDM-1 positive Klebsiella pneumoniae and Escherichia coli using the new MTS synergy method
J. Weeks, T. R. Walsh
ECCMID 2013, poster no. 1553

In vitro antimicrobial susceptibilities of Methicillin-resistant Staphylococcus epidermidis
P. C. Lindemann, R. Skjåstad, H. E. Haraldsen, O. Lutro, H. G. Wiker, H. Mylvaganam
ECCMID 2013, poster no. 1597

Evaluation of strips with concentration gradient of antifungal agents for the susceptibility determination of Candida strains
J. Meletiadis, A. Elefanti, M. Sinopi, L. Zerva, A. Velegraki
ECCMID 2013, poster no. 1583

About a bloodstream Corynebacterium striatum isolate
V. Savini, G. Gherardi, M. Favaro, C. Fontana, R. Marrollo, A. V. Argentieri, G. Dicuonzo, et al.
© Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i. 2013

Methicillin-Resistant Staphylococcus pseudintermedius Infection in a Bone Marrow Transplant Recipient
V. Savini, R. Marrollo, G. Di Bonaventura, P. Fazii, E. Carretto
J. Clin. Microbiol. 2013, 51(5):1636. DOI: 10.1128/JCM.03310-12.

In vitro susceptibility of isolates of Francisella tularensis from Turkey
S. Kiliç, B. Çelebi, B. Acar, M. Atas
Scandinavian Journal of Infectious Diseases, 2012.

Agreement of the MIC Test Strip versus Etest in MIC determination of Streptococcus pneumoniae
B. C. Haldorsen, A.-S. Furberg, Ø. Samuelsen, D. F. Vestrheim, M. Steinbakk, A. Sundsfjord
ECCMID 2012, poster no. 1658

Evaluation of the variability in the susceptibility of Acinetobacter baumannii to tigecycline in the same medium with two methods of quantitative diffusion different commercial
M. Causse, R. Tejero, M. A. Moreno, F. Solís, F. Rodríguez, M. Casal

A new reliable screening method for the evaluation of VISA and hVISA strains by "Vancomycin-Teicoplanin MIC Test Strip"
F. Campanile, D. Bongiorno, M. Perez, C. Scudieri, G. Mongelli, L. Sessa, S. Stefani
ECCMID 2011, poster no. 776

Evaluation of a new gradient-diffusion system for MIC determination with Gram-negative pathogens
V. Conte, M.M. D’Andrea, T. Giani, G.M. Rossolini
ECCMID 2011, poster no. 572

Skin and Soft Tissue Infections Following Marine Injuries
V. Savini, R. Marrollo, R. Nigro, C. Fusella, P. Fazii

The Italian Hafnia alvei strain LMG 27376 is Hafnia paralvei
Vincenzo Savini

Bacillus cereus Pneumonia
Vincenzo Savini

Laboratory Comparison of Etest®, MIC Test strip, Vitek® 2 systems, and VetMICTM microdilution panel for determining the MICs of antibiotics used in the management of Streptococcus pneumoniae infections
A. Schellnast, A. Kormann-Klement, S.Heuberger

Comparison of two commercial quantitative systems for determining the minimum inhibitory concentrations of Salmonella and Shigella species
A. Sooka, I. Mtambo, K. Keddy, G. Duncan Traill